Abstract:

Purpose: Although there is no viral-specific antiviral treatment, favipiravir has entered the routine of antiviral treatment in our country in May 2020. In this study, the intensive care unit evaluated the effects of favipiravir antiviral regime on mortality and morbidity in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acute respiratory disorder syndrome (ARDS). Instruments and Methods: Patients admitted to the intensive care unit were divided into two groups: favipiravir (Group F; n=208) and non-Group N; n=101. The treatment of the cases was organized according to current national guidelines. Clinical Decision Support Software in Metavision/QlinICU Intensive Care Unit; Acute Physiology and Chronic Health Assessment-II, Comorbidity, Ordinary Organ Insufficiency Assessment Score, Aspartate Aminotransferase, Area Aminotransferase, Urine, Creatine, Lactate Dehydrogenase, Ferritin, C-reactive Protein (CRP), Pro-BNP, D-dimer, Fibrinogen, White Blood Cells, Nutrophil Number (NEU), Lymphocytes Number (LYM), NEU/LYM, CRP, T1 Acceptance (0. Hours), Acute Parameters (22.2 T) and T3 Hours (T3 Hours) are obtained with the excessive Value of Query (Structu) The primary result is mortality; the secondary results are possible drug-related organ toxicities, sudden changes in the level of acute phase reactors, the need for continuous renal replacement therapy (CRRT), the duration of stay in the hospital, the days of ventilation. Results: 108 women (35 percent), 201 men (65 percent) and a total of 309 incidents were evaluated. In the demographic data of the groups, there was no statistically significant difference between comorbidity frequency, mortality rate, CRRT need and secondary infection. The average increase of 107.66±628.99 units between t1 and t3 measurements in group F was statistically significant. During the follow-up period, the neutrophil/lenphocytes rate (NLO) and the last NLO were found lower than the initial value. The result: Favipiravirin used in the treatment of SARS-CoV-2 ARDS has not been found to be superior in preventing mortality.

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