Özet:

Backgrounds: Atrial fibrillation (AF) occuring in the acute phase of Myocardial Infarction (MI) is an important predictor of in- hospital and long-term mortality. The aim of this study is to investigate the effect of MgSO4 therapy on the maximum P wave duration(P max), minimum P wave duration (Pmin), P wave dispersion (PWD) and its relationship with AF in acute anterior ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary interventions (PCI). Methods: Fifty-five patients (mean age 55.1 ± 6.7) who were hospitalized with diagnosis of STEMI and 47 normal individuals (mean age 54.1 ± 7.2 years) were prospectively enrolled. Percutaneous coronary intervention was performed to all MI patients with conventional methods. All patients' demografic and clinical features were recorded. In STEMI patients group, admission and fifth-hour electrocardiographic parameters (Pmax, Pmin, PWD) were measured in patients with Mg therapy(n=25) and patients without Mg therapy(n=30). Results: Pmax and PWD values were higher in acute MI patients than the control group. (118.7 ± 6.3 msn vs. 107.1 ± 3.4 msn, 40.5 ± 4.8 msn vs. 30.2 ± 3.3 msn; p = 0.01 and p = 0.01, respectively ). In Mg(+) group, Pmax and PWD values were significantly lower on fifth-hour ECGs compared to admission ECGs( 121.4 ± 7.1 vs 109.6 ± 4.1 msn, 41.3 ± 4.7 vs 30.7 ± 2.9 msn, p = 0.01 and p = 0.01). In Mg(-) group , only Pmax values were significantly lower on fifth-hour ECGs compared to admission ECGs(116.6 ± 4.7 vs 114.7 ± 4.2 msn, p = 0.04). PWD decrease after treatment was significantly higher in Mg (+) group than Mg (-) group ( 10.6 ± 5.1 vs 2.1 ± 1.4 msn, p = 0.01). Conclusions: Mg treatment causes significant reduction in PWD values in patients with acute anterior STelevation MI after primary PCI. This result suggests that Mg treatment may be useful especially in high-risk patients in terms of developing AF.

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