Özet:

Purpose: Our purpose in the study is to experimentally investigate whether manuka honey, a powerful anti-inflammatory and antioxidant, has an effect on the development of vasospasm in the subaraknoid bleeding model created in the rats' femoral artery. Method: Twenty-four Wistar-Albino species rats were divided into three groups: the first group (n = 8), the control group; the second group (n = 8), the vasospasm group; and the third group (n = 8), the vasospasm + honey treatment group. The wall thickness (W) and lumen diameter (L) of the femoral arteries were morphometrically measured. SPSS was used for statistical analysis. The subgroup analyses were performed with the Mann Whitney U test and interpreted with the Bonferroni correction. The statistical alpha significance level was considered p < 0.05. Results: A statistically significant difference was found in the L and W groups' average (p < 0,001, p = 0,001). The L average for Group 2 was statistically significantly lower compared to Group 1 and Group 3. The W average was significantly high (p < 0,001 for all). There is no statistically significant difference between the L and W average of Group 1 and Group 3 (p = 0,064 p = 0,954). Discussions: Manuka honey shows its antioxidant and anti-inflammatory effect by inhibiting the levels of inflammatory cytokines and lipid peroxidation such as plasma TNFα, IL-1β, IL-6. Antiinflammatory and antisithocin therapy has been found in various studies in which subaraknoid bleeding prevents ischemic complications. The study we have done has statistically demonstrated that with the anti-inflammatory and antioxidant properties of Manuka honey, the vasospasm model experimentally created in the femoral artery of the rats has been successful in preventing vasospasm.

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