Özet:

In recent years there are many trials about new alternatives to surgical abortion. Our purpose was to determine the success rate of two known drugs; methotrexate&misoprostol. A trial was performed to 100 women attending to our hospital whose pregnancy was < 63 days and who wanted medical abortion. 7 days after injecting methotrexate (50 mg/m2) we administered intravaginal misoprostol (400 μg). If no abortion occurred in the first 24 hours of misoprostol administiration we repeated the misoprostol on the second day. For all women we made vaginal ultrasonography before and after the study. Six patients preferred surgical abortion in the second day of methotrexate injection without any reason, 2 woman aborted spontaneusly before the misoprostol. 88 women aborted completely, whereas 4 women had incomplete abortion and we made them vacuum curretage. 50 women aborted in the first 24 hours, 38 aborted following the second dose of misoprostol. In those women who aborted succesfully vaginal bleeding and abdominal pain started in 3±1 hours. There was no need for surgical procedures becouse of hemorrage. The side affects of methorexate or misoprostol were infrequent. Misoprostol administiration 7th days after methotrexate injection may be a good alternative to surgical abortion procfedures.

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