Özet:

Aim: Visfatin/pre-B cell enhancement factor stimulates the production of inflammatory cytokines released from adipose tissue such as TNF-α and IL-6, which are shown to be related to the pathogenesis of insulin resistance, diabetes, dyslipidemia, inflammation, autoimmune diseases, and atherosclerosis. Our aim was to evaluate plasma visfatin concentrations in patients with autoimmune hypothyroidism and its relationship with thyroid autoimmune and atherosclerosis. Material and Method: Thirty-five patients with newly diagnosed Hashimoto's thyroiditis (32 women/3 men, average age 43.8±9.6 years) and 18 healthy controls (17 women/1 men, average age 43.3±5.2 years) were enrolled in the study. Anthropometric measurements, carotid intima-media thickness (CIMT), serum anti-Tg, anti-TPO, hsCRP, homocysteine, lipo(a), ApoA, ApoB1, β-2 microglobulin, insulin, glucose, visfatin, IL6, TNF-α, oxidized-LDL concentrations, lymphocyte subgroups and lipid profile were investigated both before and after thyroid hormone replacement therapy. Serum visphatin concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Results: Mean serum visfatin concentrations were similar between autoimmune hypothyroidism group and control group (6.29 ± 1.63 ng/ml to 6.36 ± 1.51 ng/ml, p>0.05) and it was not correlated with thyroid autoimmunity and atherosclerosis markers. Plasma visphatin, oxidized LDL, IL-6, and TNF-α concentrations did not differ statistically between the control group and hypothyroid patients both before and after the therapy. The cardiovascular risk factors for systolic and diastolic blood pressure, HOMA-IR index, triglyceride, Apo B and ApoB/ApoA, homocysteine, β-2 microglobulin, and CIMT were found to be elevated in patients. Ox-LDL, cholesterol, homocysteine, and proteinuria concentrations were positively correlated with anti-Tg concentrations. Conclusion: Serum visfatin concentrations were not associated with thyroid autoimmunity and atherosclerosis.

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