Abstract:

Cardiovascular diseases (CVD) are a major public health problem worldwide, causing high mortality rates, morbidity, and high treatment costs. Through these facts some non-pharmacological alternatives such as the ingestion of functional foods and the practice of physical exercise have been studied with the intention of preventing and treating the CVDs. Objective: To verify if the consumption of red wine, whole grape juice and the practice of aerobic exercise promote cardiac hypertrophy in Wistar rats. Method: 48 male Wistar rats, aged six months, divided into four experimental groups: wine, juice, exercise and control were used. All animals underwent gavage for eight weeks. The aerobic training was performed individually, in a motorized activity wheel, during the two weeks of adaptation and eight weeks of intervention with loads implementation. After surgery, a surgical procedure was performed to remove the organs, followed by dissection of the hearts for analysis. Results: Pre and post intervention Lee values showed significant differences in all groups. In absolute heart weight there was an increase due to tibial size for all groups in relation to the control. The relative weight of the heart presented significant differences for all groups in relation to the control group, suggesting cardiac hypertrophy. Conclusion: The consumption of substances such as grape juice and red wine, as well as the regular practice of physical activity, help in the process of cardiac hypertrophy in Wistar rats.

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