Özet:

Objective: In our study, it was aimed to determine the role of sex hormone binding globulin and highly sensitive C-reactive protein in the prediction of gestational diabetes mellitus. Methods: Between February 2017 and July 2017, 6-14 women who applied to the pregnant outpatient clinic of our clinic for routine antenatal control were included in the study. 99 pregnant patients at gestational week were included. Age, gestational week, last menstrual period, gravida, parity, weight, height, history of GDM, macrosomia and polyhydramnios, smoking, mode of delivery, birth weight, sex hormone binding globulin and high sensitive C-reactive protein values of the patients were recorded. Results: There was no significant difference between gestational diabetes and control groups in terms of age, gravida, parity, gestational week at birth and smoking (p>0.05). Body mass index, history of gestational diabetes in the previous pregnancy, development of macrosomia in the current pregnancy, development of polyhydramnios, birth weight and cesarean delivery rate were found to be significantly higher in the gestational diabetes group than in the control group. The sex hormone binding globulin level was 213.4±111.33 nmol/L in the gestational diabetes group and 251.64±137.94 nmol/L in the control group, and there was no significant difference between the two groups (p=0.325). The highly sensitive C reactive protein was 10.12 ± 11.36 mg/L in the gestational diabetes group and 5.18 ± 5.91 mg/L in the control group, with statistically significant differences between the two groups (p=0,004). High-sensitive C reactive protein >3.25 mg/L has a gestational diabetes prediction sensitivity of 78, specificity of 62% found. The result: Early diagnosis was extremely important in the reduction of maternal and fetal mortality and morbidity, and it was concluded that high-sensitive C reactive protein, considered in the first trimester for gestational diabetes mellitus, was predictive.

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