Özet:

ABSTRACT Objective: We aim to investigate the relationship between demographic characteristics and preoperative laboratory findings with the discordance between intraoperative frozen section diagnoses and final diagnoses in patients undergoing surgery with endometrial hyperplasia with atypia. Methods: The study included 154 patients who underwent surgery for endometrial hyperplasia with atypia and who received intraoperative frozen section (IFS) diagnosis between January 2015 and January 2021. Frozen section diagnoses and the final diagnoses of the patients were compared. Patient groups were split into two: patients with an IFS diagnosis concordant and patients with an IFS diagnosis discordant with the final diagnosis. These two groups were compared regarding body mass index (BMI), age, systemic diseases, laboratory parameters and ultrasonography findings. Results: When final diagnoses and IFS diagnoses were contrasted, the results were concordant in 126 patients and discordant in 28 patients. The agreement rate was 81.8% (Kappa = 0.635; p < 0.001; significant agreement). When the concordant and discordant groups were compared regarding demographic characteristics and preoperative laboratory findings, it was found that the BMI was higher, and the rate of complex atypia in the preoperative pathological examination was higher in the discordant group (p < 0.05). Other inflammatory markers and demographic variables were not significantly different between groups (p > 0.05). Conclusion: Among patients operated for endometrial hyperplasia with atypia, IFS diagnoses were mostly concordant with the final diagnoses. It should be kept in mind that the discordance rate may be higher in atypical hyperplasias with complex structure and in patients with high BMI.