Özet:

Colorectal cancer is defined as malignant occurrences observed in the large intestine and rectum. It is a disease whose etiopathology has known to be influenced by environmental and genetic factors that are not yet clearly understood. We aimed to investigate the relationship between colorectal cancer and gene polymorphisms of leptin (LEP) and leptin receptors (LEPR), which play an important role in regulation of nutrient uptake and regulation of nutrient uptake and energy balance secreted by adipocytes. The study included 55 patients with colorectal cancer and 54 healthy individuals. DNA was obtained from the blood of individuals by DNA isolation kit method. LEP rs7799039 and LEPR rs1137101 gene polymorphisms were analyzed by PCR-RFLP method. The statistical analysis of the results shows that AG genotype of LEPR rs1137101 gene polymorphism was found to increase the risk of disease 2.6 times (p <0.05). However, no significant correlation was found between colorectal cancer and LEP rs7799039 gene polymorphism (p> 0.05). As a result of our study, it was determined that LEPR rs7799039 gene polymorphism may be effective in the etiopathogenesis of colorectal cancer. As a further study, these gene expression levels should be investigated in large populations.

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