Özet:

Thyroid disease is the second most common endocrine disease to affect women of reproductive age. Gestational Diabetes Mellitus is defined as glucose intolerance that comes out or is first recognized during pregnancy, and disappears after delivery. And the incidence is increasing. Thyroid function tests disorder and high HbA1c value which detected in early pregnancy, that the whether there is a risk factor for developing GDM in later stages of pregnancy. METHODS: Eighty-two women in weeks 6-20 of pregnancy attending the internal medicine clinics and the Obstetrics and Gynaecology Clinics of Merzifon Karamustafa Paşa Government Hospital between January 2013 and July 2013 were investigated retrospectively in this study. Serum levels of TSH, fT4, fT3, FBG, HbA1c and development of GDM were assessed in all cases. Statistical analyzes were performed using SPSS 15.0 software. P values <0.05 were considered statistically significant. RESULTS: Thyroid gland dysfunction was found 42 of all patients.Hypothyroidism was found 20 (%24.4) of cases and hyperthyroidism was found 22(%26.8) of them.The prevalence of family history was significantly higher in cases with thyroid dysfunction(p=0.01). 8(9.8% of patients were diagnosed as impaired glucose tolerance and 5(6.1% of them were diagnosed as gestational DM according to OGTT performed in 24-28 weeks of gestation. There was no significant difference in the prevalence of impaired glucose tolerance or gestational DM between two groups(p=0.0091). In addition, serum levels of fasting plasma glucose were higher in patients with thyroid gland dysfunction (p=0.0012). The average levels of HbA1c were 5.9+0.64 in patients with thyroid gland disorder and 5.1+0.33 in control group. There was a significant difference between two groups (p< 0.05). The patients with HbA1c>6 in the first trimester were found to be in higher risk for developing impaired glucose tolerance and gestational DM (p=0.03). DISCUSSION AND CONCLUSION: Thyroid gland dysfunction and high HbA1c levels in early pregnancy can be evaluated as risk factors in developing GDM. Thus,we suggest that these patients should be carefully screened during pregnancy.

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