Abstract:

Behçet’s disease (BD) is a severe in ammatory vasculitis which is very common among Turkish population. Recently, IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms are shown to be associated with several in ammatory diseases. In this study, we investigated the association of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms with BD and their probable implications on clinical manifestations of BD in a Turkish patient cohort. 116 patients and 150 healthy controls genomic DNA were studied. Allele-speci c primers were used for genotyping. No signi cant difference was found between patient and controls according to genotypic distribution and allelic frequencies of IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) (p>0.05). No statistically signi cant difference was found in genotypic or allellic distribution of the same polymorphisms according to gender or clinical characteristics between patients and controls (p>0.05). Our study is to our knowledge the rst report from Turkey regarding BD and IRGM1 (rs13361189), PTGER4 (rs1373692) and CARD8 (rs2043211) polymorphisms. IRGM gene polymorphisms seems to cause predilection for autoimmunity in certain ethnic groups but not in Turkish BD patients. CARD8 gene polymorphisms and other in ammasome related genes may play a role in immune pathomechanisms in BD and separate studies including BD patients with similar clinical characteristics are required for investigating different SNPs as a probable disease susceptibility factor. 

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