Özet:

In China, at the end of 2019, a sudden pneumonic epidemic has been to be caused by a new coronavirus called SARS-CoV-2. This rapidly spreading virus has caused a public health crisis and has quickly spread to people infected outside of China and has become a pandemic. It is believed that this new virus, originating from wounds, plays a role in the infection to humans by the interlocutor breast called pangolin. Although it has not yet been fully revealed, this new type of coronavirus, which is transmitted to pangoline from the wounds that provide a gene pool for betacoronavirus, is among the most applicable hypotheses to date that this new type of coronavirus is transformed into a partial S gene mutation in the pangole and can infect people. The ACE2 receptor in the epithelial tissues of the human respiratory system isined by holding SARS-CoV-2 with S glycoprotein in an epithopic-paratopic connection. SARS-CoV-2 is taken into the cell, completing the life cycle consisting of transcription, translation and replication, the new generation of infectious virions is transferred to the cell to infect other sensitive cells. Viral proteins, which play an important role in the life cycle of SARS-CoV-2, form the pathogenesis of the disease by perfectly managing the specificity of connectivity to the receptor, proteolithic activation, endosytosis effectiveness and the activity of the prevention of the natural immune reaction of the host. It is believed that the most important factor that distinguishes the COVID-19 infection caused by SARS-CoV-2 from other coronavirus infections is the result of SARS-CoV-2’s structural and non-structual protein activities. As a result, zoonotic coronavirus species such as SARS-CoV, MERS-CoV, and SARS-CoV-2, which occurred in recent years, have created a major public health problem. Depending on mutations occurring in coronavirus, new types are likely to appear over time. Therefore, detailed and continuous studies on the biology, pathogenesis and epidemicology of coronavirus are needed.

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