Leptin resistance and obesity are associated with reduced leptin receptors and diminished maximal leptin signaling capacity; and leptin resistance confers increased susceptibility to diet-induced obesity. In essence, the augmented leptin accompanying obesity contributes to leptin resistance. Leptin resistance promotes further obesity, leading to a vicious cycle of escalating metabolic devastation.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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