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Amaç: Ülseratif kolitin (ÜK) hastalık aktivitesine ve ciddiyetine göre sınıflandırılması klinik uygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada, nötrofil lenfosit oranları (NLR) ve platelet lenfosit oranlarının (PLR), ÜK hastalarında klinik aktivite indeksinin (KAİ) yanı sıra mukozal hastalığa göre hastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) ile olan ilişkilerinin ortaya konulması amaçlanmıştır. Materyal ve Metot: Çalışma retrospektif tek merkezli çalışma olarak planlandı. Yeni tanı almış 99 ÜK’li hastadan KAİ’lerine ve EAİ’lerine göre aktif hastalık ve remisyon grupları oluşturuldu. Kontrol grubu 56 sağlıklı bireyden oluşturuldu. Bulgular: Klinik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,10 (%90 sensitivite, %45 spesifite) ve 152,13 (%70 sensitivite, %33 spesifite) olarak saptandı. Endoskopik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,09 (%97 sensitivite, %39 spesifite) ve 151,72 (%73 sensitivite, %31 spesifite) olarak saptandı. Sonuç: Çalışmamız aktif ÜK hastalarında NLR ve PLR seviyelerinin anlamlı şekilde arttığını ve bunun klinik, endoskopik ve laboratuvar endeksleri ile korele olduğunu göstermiştir. Bu inflamatuar belirteçler tek başına ya da birlikte hastalık aktivitesini tahmin edebilir.
Purpose: Classification by activity and severity of the disease is important in clinical practice, as it determines the patient's management. In this study, the aim was to identify the relationships between neutrophil lymphocytes rates (NLR) and platelet lymphocytes rates (PLR), the clinical activity index (CAI) in UN patients, as well as endoscopic activity index (EAI) that determine the severity of the disease according to the mucous disease. Material and Method: The work is planned as a retrospective one-centric work. From 99 newly diagnosed UN patients to the CAI and the EAI, active disease and remission groups were formed. The control group was formed from 56 healthy individuals. Results: Serum NLR and PLR in clinically active patients were significantly higher compared to inactive UN and control group (p<0,01). The cutting values for NLR and PLR were 2.10 (90% sensitivity, 45% specificity) and 152.13 (70% sensitivity, 33% specificity) respectively. Serum NLR and PLR in endoscopically active patients were significantly increased (p<0,01) compared to inactive UN and control group. The cutting values for NLR and PLR were 2,09 (97% sensitivity, 39% specificity) and 151,72 (73% sensitivity, 31% specificity) respectively. The result: Our study has shown that the levels of NLR and PLR in active UN patients have increased significantly and that it is correlated with clinical, endoscopic and laboratory indicators. These inflammatory signs can predict the activity of the disease alone or together.
Objective: Classification of ulcerative colitis (UC) according to disease activity and severity is important in clinical practice because it determines the management of the patient. In this study, we aimed to investigate the relationship between neutrophil lymphocyte ratios (NLR) and platelet lymphocyte ratios (PLR) with clinical activity index (CAI) in UC patients as well as endoscopic activity indexes (EIA) that determine disease severity relative to mucosal disease. Materials and Methods: The study was planned as a retrospective single-center study. Active disease and remission groups were formed from 99 newly diagnosed UC patients according to their CAIs and EAIs. The control group consisted of 56 healthy subjects. Results: Serum NLR and PLR levels of clinically active patients were significantly higher than inactive UC and control groups (p <0.01). The cut-off values for NLR and PLR were 2.10 (90% sensitivity, 45% specificity) and 152.13 (70% sensitivity, 33% specificity), respectively. Serum NLR and PLR of endoscopically active patients were significantly higher than inactive UC and control group (p <0.01). The cut-off values for NLR and PLR were 2.09 (97% sensitivity, 39% specificity) and 151.72 (73% sensitivity, 31% specificity), respectively. Conclusion: Our study showed that NLR and PLR levels were significantly increased in active UC patients and correlated with clinical, endoscopic and laboratory indices. These inflammatory markers can predict disease activity alone or in combination.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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