Özet:

Behcet disease first described in 1937 by Turkish Dermatologist Prof Dr. Hulusi Behcet is characterized as a distinct entity by recurrent oral aphthous and genital ulceration and iridocyclitis with hypopion. The disease was named Behcet Syndrome, Morbus Behcet or Behcet Disease and took its place in the literature. Whereas family cases suggest the genetic basis of the disease, geographical distribution of the cases suggests that environmental factors may also play a role in the disease progression. BD is a chronic disorder characterized by acute attacks and simultaneous secretion of cytokines in abundance. Previous studies show that considerable number of proinflammatory cytokines, chemokins and especially type 1 helper T cell (Th1) cytokines have the effect on disease activity. Therefore, the aim of the study is to investigate promoter polymorphism of TNF-α -308(G/A) in patients with active, inactive clinical and BD symptoms in the eyes. Genomic DNA isolated from 2ml blood sample taken in EDTA containing tube from control groups and BD patients applying to Dermatology and Ophthalmology Departments. Cytokine polymorphisms analyses were performed from DNA samples using PCR based RFLP method. No significant differences were found between control and patient groups in terms of promoter polymorphism of TNF-α -308(G/A) in the study. We believe that new studies with larger number of patients are needed to get significant results in promoter polymorphism of TNF-α -308(G/A)

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