Abstract:

It was aimed to evaluate the effects of using marbofloxacin, diclofenacsodium and methylprednisolone on serum cytokine levels in rats with experimental endotoxemia with LPS. In the study, 186 rats were randomly divided into 5 equal groups after the control group (n: 6) was separated. Blood samples were taken from the control group at 0 hour. LPS (4mg/rat) was administered intraperitoneally (IP) to induce endotoxemia in rats. To treat sepsis developing after endotoxemia, marbofloxacin 100mg/kg, diclofenacsodium 10 mg/kg, methylprednisolone 10 mg/kg were administered by IP route. Serum cytokine values were measured by taking blood samples under thiopental anesthesia at 1, 2, 4, 8, 12 and 24 hours following drug administration. The data obtained in the study showed a great deal of similarity to naturally occurring sepsis. When cytokine levels were examined, it was determined that the application of diclofenacsodium and marbofloxacin alone did not have an effect in the treatment of sepsis, but methylprednisolone application could be effective in case of single or combined application. It is suggested that corticosteroid administration alone or in combination with antibiotics and NSAIDs may be beneficial for increased cytokine levels with sepsis.

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