Özet:

Purpose: Determination of vitamin D levels in cases of chronic obstructive lung disease (KOAH) is also intended to determine the relationship between vitamin D levels and respiratory function test (SFT) and arterial blood gas (AKG) parameters. Tools and Methods: The study was taken with 71 KOAH phenomena in a stable period with 20 healthy control phenomena. The demographic data of the KOAH events, cigarette stories were recorded and the AKG values were measured with SFT. All plasma 25-OH D levels were studied using the HPLC (High-Performance Liquid Chromatography) method. Results: There is no statistical difference in age and gender between the COPD and the control group (P>0.05). The average plasma 25-OH D levels were found at 8.07±5.09 ng/mL in the KOAH group and 12.27±5.50 ng/mL in the control group. The average plasma 25-OH D levels were statistically significantly lower (P=0.002) according to the control group in the KOAH group. When the events of KOAH were classified by the severity of air flow restriction, 18 of the events were GOLD II (19.8%, 30 (33%), GOLD III and 23 (25.3%) in GOLD IV. There is no statistical difference in plasma 25-OH D levels (P>0.05) among the events of KOAH GOLD II-III-IV. In KOAH cases, the correlation between plasma 25-OH D levels and AKG parameters was not detected, while the positive correlation between plasma 25-OH D levels and FEV1 (second challenging expiratory volume) and FVC (hard vital capacity) was detected (r = 0.268, P = 0.024 and r = 0.494, P = 0,000 respectively). Result: The findings of the study suggest that plasma 25-OH D levels may be low in cases with KOAH and may be a contribution of decreased 25-OH D levels, especially in the deterioration of respiratory functions.

Anahtar Kelimeler: