Özet:

Mucosa-associated lymphoid tissue lymphoma, as a type of extranodal lymphoma, originates in various organs. Low-grade mucosa-associated lymphoid tissue lymphomas often tend to recur after surgical resection, radiotherapy and chemotherapy. Here, we report a case of intestinal mucosa-associated lymphoid tissue lymphoma with long-term remission after systemic chemotherapy. A 27-year-old male patient admitted to our clinic due to symptoms of abdominal pain, weight loss and fever. Physical examination revealed diffuse tenderness throughout the abdomen. Gastroduodenoscopy revealed nodular lesions in the duodenum. There was a thickened bowel wall in the left hypochondrium with several mesenteric lymphadenopathies on the abdominal tomography. Duodenal biopsy was composed of centrocyte-like cells, with infiltration of the lamina propria, and was positive for B cell surface markers, including CD20. Helicobacter pylori was found to be negative. The diagnosis of low-grade mucosa-associated lymphoid tissue lymphoma was made. The patient has had sustained clinical, endoscopic, histological, and radiological remission for four years after six courses of cyclophosphamide, vincristine, doxorubicin and prednisone chemotherapy. In conclusion, although surgery is the first-line therapy in localized low-grade mucosa-associated lymphoid tissue lymphoma, it may be possible to induce long-term remission with cyclophoshamide, vincristine, doxorubicin and prednisone chemotherapy alone.

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