Abstract:

The aim of the work. Investigate and select the optimal excipients into the composition of tablets based on dried extracts herbs of Geranium sanguineum L., Geranium sibiricum L. and essential oil of Salvia sclare for local application in the oral cavity. Materials and Methods. The composition of tablets includes a pharmaceutical composition containing dry extracts herbs of Geranium sanguineum L. and Geranium sibiricum L., essential oil of Salvia sclare, and also excipients. The influence of excipients on the pharmaco-technological properties of the tablets was studied by the indicators: the pressing process, the appearance of tablets, the uniformity of mass, resistance to crushing of tablets, friability, time of disintegration. Results and Discussion. The results of the dispersion analysis of experimental data showed that the process of pressing tablets with microcrystalline cellulose (MCC) 102, sodium croscarmellose and neusilin UFL 2 proceeded uniformly, without adhesion of the powder masses to the press tool. The tablets with neusilin UFL 2, compactrol, DI-PAC and prosolv SMCC 90 had the best appearance. The uniformity of mass within ± 5% provided the following excipients: compactrol, emcompress, corn starch, pregelatinized starch, sodium stearyl fumarate, basic magnesium carbonate, MCC 102, mannitol 60. The tablets with highest resistance to crushing were able to get with neusilin US 2, MCC 200, sodium carboxymethyl starch, microcelac 100, DI-PAC and magnesium stearate. The neusilin UFL 2, emcompress, MCC 102, pregelatinized starch, ludipress and stearic acid allowed to obtain the tablets with the least friability. The tablets with the sodium croscarmellose, aerosil 200, MCC burst, mannitol 60, emcompress and sodium stearyl fumarate were disintegrated the fastest.  Conclusions. The influence of 30 excipients on the pharmaco-technological properties of tablets with plant extracts and essential oil were studied. According to the totality of the studied indices, the best combination of excipients for further study was selected in order to develop the optimal composition and technology of the tablets for topical application in the oral cavity.

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