Özet:

Cisplatin is a frequently used chemotherapeutic in many types of cancer, especially urological cancers. Despite its efficacy in the treatment of cancer, it causes various toxic side effects such as nephrotoxicity, neurotoxicity and ototoxicity. The aim of this study was to determine the protective role of olive oile extract of propolis (OEP) with biochemical and histopathological approaches to cisplatin induced toxicity. Sixty-four adult male Wistar rats were divided into eight groups, control, propolis (100 and 200 mg/kg, orally daily for 10 days) and combined therapy (propolis 10 days before and after CP injection). Haematological (Wbc, Rbc, Mpv, Hgb, Htc, Mcv, Mch, Mchc, Lym, Neu), biochemical (triglyceride, total cholesteol, HDL and LDL-cholesterol, glucose, BUN, uric acid and testosterone level), epididymal sperm concentration, sperm motility, and histological studies. According to the results, cisplatin has negative effects on hematological, biochemical parameters, and sperm motility compared to control group. Administration of pre-cisplatin propolis ameliorated wbc, hct, mcv, mchc, neu levels. The administration of OEP prior to CP normalized the increased BUN and uric acid levels induced by CP. Interestingly it was also revealed that the testosterone levels increased in the OEP groups compared to the control group. Additionally, the combined administration of CP with OEP normalized the decreased testosterone levels induced by CP, particularly pre-treatment OEP. As a results, propolis, a natural product with numerous useful biological effects, was shown to a have protective as well as amelioration and normalizing effect on CP-induced damage.

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