Abstract:

Aim: To investigate the clinical course of COVID-19 in different trimesters of pregnancy by evaluating the demographic, clinical and laboratory data of pregnant women who applied to the Emergency Service. Materials and method: Cases were examined in 3 groups as asymptomatic, mild symptomatic and severe disease according to symptoms and oxygen saturation. High levels of CRP, ferritin, D-dimer and lymphopenia in blood tests were considered as poor prognostic factors. Results: Of 678 pregnant women with COVİD-19 , 118 (17.4%) were in the first trimester, 261 (38.5%) were in the second trimester and 299 (44.1%) were in the third trimester. A total of 257 (37.9%) COVID-19 (+) pregnant women were hospitalized and 120 of them were due to COVID-19 infection without any obstetric indication. Severe disease was detected in 57 (8.4%) of the cases; 29 of them (50.9%) were in the 2nd trimester and 26 (45.6%) were in the 3rd trimester. The incidence of severe disease was statistically significantly higher in the later weeks of pregnancy compared to the first trimester (p=0.004). When the distribution of the poor prognostic laboratory criteria according to trimesters was examined, 22.9% of pregnant women with COVID-19 had at least one poor prognostic laboratory criterion in the first trimester, while this rate was 41.7% and 63.9% in the second and third trimesters, respectively (p<0.001). Conclusion: In this study, we observed that the course of the disease in COVID-19 positive pregnant women is more severe in the later weeks of pregnancy than in the first trimester.

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