Background and Design.- PAP and PSA are known to be serum markers for prostate cancer, and the use of immunohistochemical methods to determine their localization is a well established procedure. Aim of the study is to determine the correlation between immunohistochemical staining of PSA and Gleason grade of tumor and pretreatment serum PSA levels. Radical prostatectomy specimens of 29 patients were stained by a Biotin-Streptavidin method. We used immunoperoxidase staining to assess the effect of grade on the PSA content of prostate cancer by counting 7494 acini. 34 cancer foci (grade 2-4) were stained. The intensity of PSA staining was graded by comparison with the benign epithelial cells on the same slide.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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