Abstract:

In this study, the aim was to determine the protective effects of Quersetin in the nephrotoxicide induced by 5-florourasil (5-FU) in rats. In our study, 40 adult male rats weighing about 200-250 g were used, and the rats were randomly divided into five groups. According to the experimental protocol on rats, Quersetin and 5-FU were applied, and at the end of the experimental study intrakardial blood samples were taken and decapited under anesthesia from rats. The urine, creatine and blood urine nitrogen (BUN) values in serum samples were analyzed in the autoanalyzer. The malondaldehyde (MDA), superoxide dismutase (SOD), glutation peroxidase (GPx), interlökin-33 (IL-33), aquaporin-1 (AQP-1) and Nefrin parameters in kidney tissues were analyzed using commercial ELISA kit. Moreover, the triple painting of Mallory, modified by Crossman, took the kidney tissue to a histopathological assessment. Serum urine, creatine and BUN levels controlled significantly increased in the 5-FU group compared to the 100+5-FU and 100 groups. 5-FU-induced renal oxidative stress has an antioxidant activity. Also, 5-FU warned inflammation by increasing the renal level of IL-33 and inhibited these increases in curcumin. The levels of AQP-1 and Nephrin were not different between the experimental groups. Especially high doses prevented histopathological changes caused by 5-FU. As a result of this study, it was found that curcetin significantly prevents 5-FU-resurgency nefrotoxicity in mice.

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