Görüntüleme
22
İndirme
1
Amaç: Tokat ilinde kronik hepatit B tanılı hastalarda Hepatit Delta Virüs (HDV) ve Tork Teno Virüs (TTV) araştırması yapıldı. Gereç ve Yöntemler: Çalışma Ocak 2015-Temmuz 2015 tarihleri arasında Gaziosmanpaşa Üniversitesi Tıp Fakültesi Mikrobiyoloji Anabilim Dalında gerçekleştirildi. Çalışmaya Kronik HBV’li 110 hasta (58’i kadın, 52’si erkek) ve 90 sağlıklı birey dahil edildi. Hasta kanlarından izole edilen TTV-DNA ve HDV-RNA’ların polimeraz zincir reaksiyonları (PZR) yapıldı. Ayrıca hastalarda aspartat aminotransferaz (AST), alanin aminotransferaz (ALT) değerleri de çalışıldı. Bulgular: Hasta numunelerinin 108’i HDV-RNA negatif, 2’si (%1,81) HDV-RNA pozitif olarak tespit edildi. Sağlıklı bireylerin tümünde HDV-RNA negatif bulundu. TTV çalışmasında ise 110 numunenin 106’sı (%96,4) TTV-DNA pozitif olarak bulunurken, 4’ü TTV-DNA negatif olarak tespit edildi. Sağlıklı bireylerde ise 90 numunenin 86’sının (%95,35) TTV-DNA pozitif, 4’ünün (%4,65) TTV-DNA negatif olduğu tespit edildi. HDV-RNA pozitif olan hastalarda ALT ve AST değerleri arasında istatiksel olarak anlamlı bir ilişki tespit edilirken (p<0,05), TTV pozitif olan hastalarda ise anlamlı bir ilişki yoktu (p>0,05). Sonuç: Tokat ilinin, HDV enfeksiyon oranı, Türkiye ortalamasının oldukça altında, dünya genelinde ise, çok düşük endemisite grubuna dahil bölgeler arasında olduğu görüldü. Tokat’ta ilk defa araştırılan TorkTenovirüs ise %96 oranı ile dünya ve Türkiye ortalamasının oldukça üzerindedir. Kronik hepatit B enfeksiyonlu hasta grubunda araştırılan TorkTenovirüs ve hepatit deltavirüs enfeksiyonları arasında istatistiksel açıdan anlamlı bir ilişki saptanmamıştır.
The study was conducted in patients with chronic hepatitis B in the province of Tokat with Hepatitis Delta Virus (HDV) and Tork Teno Virus (TTV). Tools and Methods: The study was conducted between January 2015-July 2015 at the Faculty of Medicine of the University of Gaziosmanpaşa in the Department of Microbiology. The study included 110 patients with chronic HBV (58 women, 52 men) and 90 healthy individuals. Polymerase chain reactions (PZR) of the TTV-DNA and HDV-RNA isolated from the patient's blood were performed. In patients, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values were also studied. Results: 108 of the patient samples were HDV-RNA negative, 2 (1.81) HDV-RNA positive. All healthy individuals found HDV-RNA negative. In the TTV study, 106 of the 110 samples (96.4%) were TTV-DNA positive, while 4 were TTV-DNA negative. In healthy individuals, 86 of the 90 samples (95.35) were TTV-DNA positive, and 4 (4.65) were TTV-DNA negative. Patients with HDV-RNA positive had a statistically meaningful relationship between ALT and AST values (p<0,05), while patients with TTV positive had no meaningful relationship (p>0,05). The result: the Tokat province, the rate of HDV infection, was found to be among the regions included in the very low endemicity group, much below the average in Turkey, and throughout the world. The first TorkTenovirus in Tokat, with a 96% ratio, is far above the world and Turkish average. There is no statistically meaningful relationship between TorkTenovirus and hepatitis deltavirus infections studied in the group of patients with chronic hepatitis B.
Aim: The aim of this study was to investigate the detection, rates and correlations of Torque Teno Virus (TTV) and Hepatitis Delta Virus (HDV) which cause superinfection and coinfection in patients with chronic hepatitis B in Tokat. Material and Methods: A total of 110 patients with chronic HBV infection (58 women, 52 men) and 90 healthy subjects were included in the study. Polymerase chain reactions (PCR) of all blood samples were performed with TTV-DNA and HDV-RNA isolations. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values of patients were also studied. Results: 108 samples of the patients were HDV-RNA negative and 2 were (1.81%) HDV-RNA positive. HDV-RNA were negative in all healthy subjects. In the TTV study, 106 of the 110 samples (96.4%) were found to be TTV-DNA positive while 4 were found to be TTV-DNA negative. In healthy subjects, 86 of 90 samples (95.35%) were TTV-DNA positive and 4 (4.65%) were TTV-DNA negative. A statistically significant relationship was found between ALT and AST values in HDV-RNA positive patients (p<0.05). There was no significant relationship between TTV positive patients (p>0.05). Conclusion: It has seen that the rate of HDV infection in Tokat province is considerably lower than the average of Turkey and in the World. Torque Teno Virus, which was investigated for the first time in Tokat, is higher than the average of Turkey and World. There was no statistically significant relationship between the infections of Torque Tenovirus and hepatitis deltavirus in patients with chronic hepatitis B infections.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
Makale Detay 
Benzer Makaleler
PDF Görüntüle
Dergi Bilgisi
Eseri Dinleyin
Alıntı Yap
Bu Sayfayı Yazdırın
Paylaş
Mendeley
