Abstract:

In this study which aimed to investigate the effect on glutathione (GSH), nitric oxide (NO) and ma-londialdehyde (MDA) levels of magnesium (Mg) playing a role in many activities for the living organism in liver tissue of mice fed with fat diet, 39 2-month Swiss albino mice were used. Mice were divided into 4 groups by weighing their bodies. Group I was fed with standart pellet food and drinking water, Group II was fed with the diet containing 31.5 % oil and drinking water, Group III was fed with the diet containing 31.5 % oil and drinking water containing 7.5 g/L magnesium sulphate (MgSO4), Group IV was fed with standart pellet food and drinking water containing 7.5 g/L MgSO4 for 12 weeks. After weighing, anesthesia was pased. After euthanasia, 0.5g from every liver tissue pieces were homogenized. The obtained supernatant NO, MDA, GSH and Mg analyzes were performed. At the end of the study, while the difference between the initial and the final weight of Group I, Group II and Group III was significant statistically (p<0.01). Compared to the control group, NO levels of the group fed with a fatty diet increased (p<0.001), and compared to the group fed with standart pellet food and Mg, NO levels of the group fed with a fatty diet and Mg increased (p<0.001). Compared to the control group, it was determined that there was a significant decrease (p<0.05) in the Mg level of the group fed with a fatty, and compared to the group fed with standart pellet food and Mg, it was determined that there was a significant decrease (p<0,05) in the Mg level of the group fed a fatty diet and Mg. MDA levels increased in the group fed with fat diet and in the group fed with fat diet and Mg, and compared to the control group, GSH levels of the group of fed standard pellet food and Mg significantly increased (p<0.001). Consequently, fat diet caused an increase in MDA and NO levels and a decrease in GSH levels. Depending on a fatty diet, it was reached the conclusion that Mg implementation could use as an alternative method in terms of that increasing NO and MDA levels decrease to normal level.