Özet:

Cancer is a serious genetic disease that occurs as a result of a series of disorders occurring in the genom. The development of high-performance new-generation sequencing technologies and the publication of data from large-scale projects have enabled the detection of many non-coded RNA (ncRNA) molecules that show different expression profiles in different cancers. Long uncoded RNA (lncRNA) and microRNA (miRNA) transcripts have been to play a critical role in the formation and progression of cancer and are available in the diagnosis/treatment of cancer. Specifically, miRNAs are small RNA molecules that control the genes expression at post-transcription level and are known to have critical roles in important processes such as metastasis, invasion, cell reproduction, differentiation, angiogenesis, which have important distinctive properties of cancer. Similarly, lncRNAs are also defined as RNA transcripts, which play an important role in the illumination of the molecular mechanism of cancer. Therefore, in this comprehensive summary, the distinctive properties of cancer with ncRNAs that are not capable of protein coding such as miRNA, lncRNA, T-UCR, but functional, have been addressed from a current perspective.