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  Citation Number 4
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Synthesis and anticonvulsant activity of substituted thiourea derivatives
2011
Journal:  
Journal of Research in Pharmacy
Author:  
DOI:  
10.12991/201115430
Abstract:

Twelve new thiourea derivatives were prepared by the reacting of 4-aminophenylacetic acide with substituted isothiocyanates. Their chemical structures were proved by means of IR, 1H-NMR, mass spectroscopic and elemental analyses. These compounds were tested at dose of 50 mg/kg for their anticonvulsant activity using by pentylenetetrazole induced seizure (PTZ) and maximal electroshock seizure (MES) tests in mice. Compound 1b, (4-{[(4-chlorophenyl)thiocarbamoyl]amino}phenyl)acetic acid, was found to be more active than the other tested compounds. The compound 1b reduced convulsions in all types of grades (from grade I to V), therefore it increased convulsive threshold. It also increased onset time from 1.20 to 2.58 sec. and survival % from 50 to 95.

Keywords:

null
2011
Journal:  
Journal of Research in Pharmacy
Author:  
DOI:  
10.12991/201115430
0
2011
Journal:  
Journal of Research in Pharmacy
Author:  
DOI:  
10.12991/201115430
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Journal of Research in Pharmacy

Journal Type :   Uluslararası

Metrics
Article : 1.111
Cite : 924
Quarter
Basic Field of Health Sciences
Q2
88/222
Details
Journal of Research in Pharmacy