Abstract:

Diabetes Mellitus is a chronic hyperglycemic metabolic disease leading to disorders of carbohydrate, lipid and protein metabolism due to deficiency of insulin function and insulin hormon secretion. By the year 2025, the World Health Organization projects more than 300 million cases worldwide. Diabetes mellitus is an independent risk factor for cardiovascular disease and this risk increases further with accompanying dyslipidemia. Diabetic dyslipidemia is characterized by hypertriglyseridemia, decreased levels of HDL-cholesterol particles and increased small and dense LDL-cholesterol particles. This lipid profile, also named as toxic triad, coexists in the patient long before diabetes can be diagnosed. In our study, we investigated diabetes prevalence and its relationship with plasma lipids and other related parameters in 30745 patients attending to our internal medicine clinic between August 2006 and May 2007. We detected high statistical correlation between fasting blood glucose and total cholesterol, triglyseride, HDL- cholesterol concentrations. Total cholesterol, TG levels were increased whereas HDL-cholesterol levels were decreased, on the other hand, blood glucose concentrations were elevated. We found out that relationships between Hba1c levels and total cholesterol, TG, HDL-cholesterol levels were statistically significant too. The majority of type 2 diabetic patients are dyslipidemic. Optimization of lipid profile in these patients is the most important intervention needed for the improvement of cardiovascular mortality/morbidity and for the reduction of risks related to the procedures of coronary death, MI, stroke and revascularization.

Keywords: