Özet:

Objective: Learning and memory disorders are associated primary or secondary with many disease which affect the quality of life negatively. In this study, possible effect of agmatine on cognitive functions have been investigated. Methods: Agmatine was applied after the disruption of cognitive functions by using amnesia or stress models in Wistar Albino rats. Muscarinic cholinergic receptor blocker scopolamine was used to create amnesia. In this model rats have been divided into 3 groups as control, scopolamine and scopolamine+agmatine. Control group has received saline, scopolamine group 1 mg/kg scopolamine, scopolamine+agmatine group 1mg/kg skopolamine and 20 min later 40 mg/kg agmatine intraperitoneally (i.p.). Animals were exposed to immobilization in order to create stress for 14 days, 4 hours per day. In this model, rats were divided into three groups as control, stress and stress+agmatine. After stress exposure saline was administered to control and stress groups and 40 mg/kg agmatine to stress+agmatine group. Animals were taken to Morris water maze and passive avoidance tests to evaluate learning and memory functions 30 min after the last injections. Results: In our study, it has been shown that agmatine treatment significantly improved learning and memory impairment induced by both scopolamine or stress. Conclusion: Based on these findings, it is thought that agmatine may have a positive effect on learning and memory functions, and also may play an important role in regulation of cognitive functions as an endogenous substance.

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