Abstract:

Aim: Management of Acinetobacter baumannii infection is usually difficult due to increase in multi-drug resistant Acinetobacter baumannii srains and rapid development of resistance to new antimicrobial drugs. It may cause nosocomial infections such as pneumonia, ventilator-associated pneumonia, urinary tract infections, blood stream infections, meningitis especially in intensive care units. The aim of this study was to evaluate the antimicrobial susceptibilities of 170 A. baumanii strains isolated from clinical specimens in our hospital. Material and Methods: A total of 170 A. baumanii strains isolated from clinical specimens in our microbiology laboratory during February 2005- May 2012 were included the study. A. baumanii isolates were identified by using BD Phoenix 100 (Becton Dickinson, USA) Amikasin, sulbactamampicillin, cefepime, cefotaxime, ceftazidime, colistin, gentamicin, imipenem, meropenem, tetracycline, trimethoprim-sulfamethoxazole, tobramycin, piperacillin-tazobactam, ciprofloxacin and tigecycline susceptibilities of A. baumanii isolates were determined by using BD Phoenix 100 (Becton Dickinson, USA) automated system and Kirby-Bauer disk diffusion method. Results: The source of A. baumanii isolates was predominantly respiratory tract, yielding 67 (39%), while 40 (23%) isolates were from blood, 36 (21%) from wound, 24 (14%) from urine, 1 (0.6 %) from catheter, 1 (0.6%) from cerebrospinal fluid. Forty two percent of A. baumanii isolates were isolated from ICU, sixteen percent from chest disease service, seven percent from orthopedic service, seven percent from general surgery service, fourteen percent from other clinic services and twelve percent from outpatient clinics. The resistance rates of A. baumanii to amikasin, sulbactam-ampicillin, cefepime, cefotaxime, ceftazidime, colistin, gentamicin, tobramycin, imipenem, meropenem, tetracycline, trimethoprim-sulfamethoxazole, piperacillin-tazobactam, ciprofloxacin and tigecycline were found 65%, 95%, 93%, 97%, 93%, 3%, 90%, 8%, 66%, 65%, 62%, 66%, 93%, 92%, and 15% respectively. The imipenem resistance rate increased significantly from 0% to 88.57% in a study period. One of the A. baumanii isolate was found to be colistin resistant in 2012. Conclusion: In this study colistin was found to be most effective antimicrobial drıug agains A. baumanii isolates. We also observed that the resistance rates of A. baumanii isolates to tested antimicrobial drugs are progressively increased in 7 years period. It is well known that wide spread use of antimicrobial drugs promotes the spread of antimicrobial resistance. Overuse and misuse of antimicrobial drugs must be taken under control immediately. Key Words: Acinetobacter baumannii, antimicrobial susceptibility, multi-drug resistance

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