Özet:

The genetic changes in some molecules that underlie malign transformation of cells can be used as markers to diagnose, monitor or characterize various forms of cancer. Though in colorectal cancer, many of the genetic changes have continued to be studied in tumor supressor genes, this study aims to clarify the expression pattern of p53, and p73 genes between normal and tumor colorectal tissues and corralate with clinicopathological features. A total of 38 tissue samples (19 normal and 19 tumor tissue)from 19 patients with colorectal cancer were included in this study. The expression of p53 and p73 have been investigated by using the RT-PCR and semi-quantitative densitometric approaches. Between the normal and tumor tissues was found no difference of p53 and p73 expression levels. In patients with high levels expression levels of p53, pathological stage was found significantly more advanced than that of the cases expressing low levels of p53, and these tumors were not metastatic. Our study suggests that the detection of expressional changes of p53, and p73 might contribute to further understanding of the tumor biology of colorectal cancer and could serve as predictive markers for patient prognosis

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