Özet:

Oxidative stress is at play in the progression of chronic renal failure (CRF) and in the genesis of atherosclerosis.The aim of the present study was to evaluate the factors that might influence the oxidativeantioxidative balance in patients on hemodialysis. The study group was consisted of 64 hemodialysis patients due to CRF. Twenty-two healthy subjects constituted a control group. We measured changes in serum superoxide dismutase and glutathione peroxidase activity, and malondialdehyde levels in chronic renal failure patients and compared with healthy control groups. Superoxide dismutase and glutathione peroxidase activity, and malondialdehyde levels were assayed with spectrophotometric methods. Superoxide dismutase activity of CRF patients group were higher than those of control group (p<0.001). Glutathione peroxidase activity of CRF patients group were lower than those of control group (p<0.001). Malondialdehyde levels in hemodialysis patients were higher than those of control group (p<0.01). Several studies of SOD activity in chronic renal failure patients have found conflicting results. We propose that the increased SOD activity could be a protective mechanism for the cells due to the hyperproduction of free radicals in chronic renal failure. Decreased serum antioxidant activity in CRF patients on hemodialysis may contribute to the increased oxidative damage and in the development of renal complications. This study indicates the existence and increased production of oxidative stress resulting from hemodialysis and disturbance in antioxidant enzyme system. Our results supports that an increase in oxidative stress may be considered as one of the major risk factors in chronic renal failure patients

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