The cancer incidence in adolescents age 15-19 years is 50% higher than that of childhood age 0-14 years and approximately 203 per million. Rates is similar in both sexes. The annual incidence increased 10% in the last 20 years. The mostcommon tumors among adolescents are lymphomas 23% , leukemias 15% , germ cell tumors 14% central nervous system tumors 9% , soft tissues tumors 9% , bone tumors 8% , endocrine neoplasm 9% , and skin carcinomas 8% . Mortalityfrom cancer in adolescents is two times higher than childhood. Cancer mortality rate for adolescents was 4/100.000 at 2003,while it was 8.6/100.000 at 1950. The overall decline in mortality from cancer is nearly %50 in the last 50 year. The 5-yearsurvival rates improved from 65% to 80% between the years 1975 and 2000. For 20 year, the total change in 5-year survivalfor adolescents cancer is 19%, while this ratio is 31% for childhood cancer. The reasons for the difference in survivalimprovement among adolescent in contrast to childhood are multifactorial. Firstly, most of the adolescent with cancer areadmitted to adult clinics and treated with protocols for adult. In addition only 10% of adolescents are entered onto clinicaltrials, while this ratio reaches 90% for children with cancer
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