Özet:

Purpose: Histopathological subtype, nuclear degree and comedonecrosis are important characteristics for the ductal carcinoma in situ (DKIS) injury of the breast. The aim of this study is to determine the relationship between the histopathological characteristics of DKIS and the p53, HER2/neu, bcl-2 and PCNA overexpression.  Methods: 40 facts diagnosed with DKIS were evaluated in terms of p53, HER2/neu, bcl-2 and PCNA overexpression using immunochemical methods. Low/intermediate degree injuries were included in group 1 (low degree DKIS), high degree events in group 2 (high degree DKIS). The histological patterns were also evaluated. Comedo type and non-comedo type DKIS groups were created. 12 of the 40 events were high, 28 low, 8 comedo type and 32 non-comedo type DKIS. In comedo-type DKIS cases, p53 and HER2/neu overexpression were observed respectively at 37.5%, while in non-comedo-type DKIS cases, this ratio was 6.5% and 3.1% respectively. In high-degree cases p53 and HER2/neu overexpression were observed respectively at 41.7 percent and 50 percent, while in no low-degree cases p53 and HER2/neu overexpression were not observed. Strong cytoplasmic painting with Bcl-2 was not observed in any of the high-degree phenomena, while 60% of the low-degree phenomena were observed. There was statistically significant difference between the groups for all these overexpressions (p<0,05). Results: P53 and HER2/neu overexpression were found associated with poor prognostic factors such as comedo type and high degree. Strong cytoplasmic painting with Bcl-2 was found associated with good prognostic factors such as non-comedo type and low degree. These results will contribute to the identification of the subtypes of DKIS with different biological behavior.

Anahtar Kelimeler: