Özet:

In this study, H4L Schiff base ligand which can form stable complexes with 4,4′-Diamino-2,2′-stilbenedisulfonic acid compound having primary diamine and disulfonic acid group in its molecular structure was synthesized. Cu(II), Zn(II) and Cd(II) complex compounds of the H4 Lligand were synthesized. Molecular structures of the compounds obtained were characterized using analytical and spectroscopic methods. Gram positive(5), gram negative(6), probiotic bacteria(2) antimicrobial and antifungal activities (MIC, MBC) of all compounds were studied. MIC values of the compounds on indicator bacteria at concentrations of 500, 250, 62.5, 31.2, 15.63 and 7.81 μg/mL, 250 mg/mL for H4L, 31.5 mg/mL for [Cu2H2L(CH3COO)2(H2O)2], 62.5 mg/mL for [Cd2H2LCl2(H2O2] and 125 mg/mL for [Zn2H2L(CH3COO)2(H2O)2], the complexes were determined to be more effective than the ligand. Bactericidal effects were determined in the MBC test at concentrations of 500-250 mg/mL. In the agar well diffusion test, the compounds were tested only at 500 mg/ml and different inhibition diameters were determined.

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