Özet:

INTRODUCTION: to investigate maternal and perinatal outcomes in patients with intrahepatic cholestasis of pregnancy METHODS: This study was conducted between 2008 and 2011 on patients with intrahepatic cholestasis of pregnancy. The study was designed in retrospective manner. All data were collected from hospital records. Total serum bile acid ≥ 15micromol/L or pruritus with increased serum transaminase levels were accepted as diagnostic criteria for intrahepatic cholestasis of pregnancy. The rate of preterm birth, fetal growth restriction and intrauterine fetal demise were the main outcomes. Maternal and neonatal records were also noted RESULTS: A total of 24 patients with intrahepatic cholestasis of pregnancy were enrolled the study. The mean patients’ age and weight and BMI were 26.4±5.8 and 78.6±12.1 and 30.1±5.7 respectively. The mean serum total bile acid level was 112.7±87.1 mikromol/L. The mean gestational time was 263.4±9.9 at time of labor. The mean neonatal birthweight and the five-minute APGAR score 2975±454 g. And 9.7±0.5 respectively. Cesarean delivery rate was 25%. The rate of fetal growth restriction, preeclampsia and preterm birth were 8.3%, 12.5% and 25%. A patient was died due to postpartum hepatic failure. DISCUSSION AND CONCLUSION: A physician should consider other clinical pathologies that can cause maternal death before the diagnosis of intrahepatic cholestasis of pregnancy

Anahtar Kelimeler: