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 Görüntüleme 21
 İndirme 3
Preoperatif kemoradyoterapi uygulanan lokal ileri rektum kanserli hastalarda tedavi öncesi hemoglobin düzeyinin prognostik rolü
2018
Dergi:  
Cukurova Medical Journal
Yazar:  
Özet:

Purpose: This study aims to systematically evaluate the relationship between baseline blood count levels, simply and basically initiated,  and treatment response in locally advanced rectal cancer  patients treated with neoadjuvant chemoradiotherapy. Materials and Methods: This retrospective study included 123 locally advanced rectal cancer patients who were treated with neoadjuvant chemoradiotherapy followed by surgery. Pretreatment Hb level was assessed as an independent variable for the whole study sample .The primary endpoint was the impact of pre-treatment Hb levels on overall survival.  Results: At a median follow-up of 40,3 months (1,4-92 months). A Hb cut-off value of 12.5 g/dl (AUC=0.673, %95 0.564-0.781) was identified by using ROC analysis. Following the stratification of patients at this cut-off point into two groups: normal-Hb (nHb; Hb>12) and low-Hb (dHb≤12), the comparative survival analysis demonstrated that the patients in the nHb group had significantly increased OS than those in the dHb group, and retained its independent significant association  with survival outcomes in the multivariate analysis.  Conclusion: Knowledge of pretreatment hematological parameters appears to be an important prognostic factor in patients with rectal carcinoma. 

Anahtar Kelimeler:

Preoperative chemoradiotherapy applies the prognostic role of pre-treatment hemoglobin levels in patients with local advanced rectum cancer
2018
Yazar:  
Özet:

Purpose: This study aims to systematically evaluate the relationship between baseline blood count levels, simply and basically initiated, and treatment response in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy. Materials and Methods: This retrospective study included 123 locally advanced rectal cancer patients who were treated with neoadjuvant chemoradiotherapy followed by surgery. Pre-treatment Hb level was assessed as an independent variable for the whole study sample.The primary endpoint was the impact of pre-treatment Hb levels on overall survival.  Results: At a median follow-up of 40.3 months (1,4-92 months). A Hb cut-off value of 12.5 g/dl (AUC=0.673, 95% 0.564-0.781) was identified by using ROC analysis. Following the stratification of patients at this cut-off point into two groups: normal-Hb (nHb; Hb>12) and low-Hb (dHb≤12), the comparative survival analysis demonstrated that the patients in the nHb group had significantly increased OS than those in the dHb group, and retained its independent significant association with survival outcomes in the multivariate analysis.  Conclusion: Knowledge of pre-treatment hematological parameters appears to be an important prognostic factor in patients with rectal carcinoma.

Anahtar Kelimeler:

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Cukurova Medical Journal

Alan :   Sağlık Bilimleri

Dergi Türü :   Uluslararası

Metrikler
Makale : 2.296
Atıf : 1.845
2023 Impact/Etki : 0.075
Cukurova Medical Journal