Özet:

Introduction: Hospitalized coronavirus disease-2019 (COVID-19) individuals were studied in terms of their thyroid functioning with respect to their disease severity and mortality rate. Methods: The thyroid function tests of 781 in patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pneumonia outside the intensive care units were examined as part of this retrospective investigation, which was conducted in a single center. Data from the patients were categorized as deceased or discharged. Based on their diagnostic categories, the patients were grouped according to their thyroid stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) values. TSH, fT4, and fT3 levels were assessed within 24 h after admission. Results: Of the 781 patients who had COVID-19 of, 726 were discharged and 55 died. When compared to the discharged group, deceased patients exhibited lower than normal TSH and fT3 levels (p<0.001; for both). Notwithstanding, there was no significant difference between deceased and discharged patients regarding fT4 values. 115 (14.7%) patients had thyroid dysfunction (16 patients had elevated TSH, 99 had TSH levels below the reference value) and 154 (19.7%) patients had non-thyroidal illness (NTI). The individual effect of thyroid function tests on patient death was investigated using the log rank test, and fT3 levels were found to be significant for predicting mortality. Conclusion: Our findings imply that thyroid function tests, especially in severe patients, may have prognostic significance. Lower fT3 and TSH levels may be associated with systemic inflammation, which could be a prognostic value associated with the disease state and mortality rate. fT3 was shown to be an independent risk factor for death. As a result, approximately 15% of the patients were observed to have thyroid dysfunction and 19.7% were NTI, which were all linked to severe disease status.

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