Özet:

Aim: Glucagon-like peptide 1 (GLP-1) is an important incretin hormone secreted from enteroendocrine L cells. GLP-1 analogs are used for the treatment of diabetes and obesity. Ovarian hormones are well known in playing critical roles in regulating cardiovascular functions. Cardiovascular disease incidence increases in postmenopausal women. The aim of this study was to investigate the effect of administration of liraglutide, a GLP 1 analogue, on cardiac function and cardiac tissue oxidative stress in ovariectomized rats. Material and Methods: Thirty two young female Wistar albino rats were used in the study. Subjects were randomly divided into control, liraglutide-treated control, ovariectomized (OVX), and liraglutide-treated OVX groups. Ovariectomy and sham surgical procedures were performed in 2-month-old female rats. Liraglutide treatment (150μg/kg, subcutaneous, 14 days) was started five weeks after the ovariectomy operation. After measuring the heart rate and blood pressure at the end of the 14-day period, the animals were sacrificed, brown and white adipose tissue weights, and heart tissue malondialdehyde (MDA), reduced glutathione (GSH), nitrate, glycogen and ascorbic acid levels were measured. Results: While there was no difference between all groups in terms of heart rate, blood pressure was statistically significantly decreased in the liraglutide-administered groups. MDA and ascorbic acid levels did not change significantly between all groups. GSH levels were increased in the liraglutide-treated OVX group. It was found that the cardiac glycogen level was increased in the OVX group treated with OVX and liraglutide compared to the control group. Nitral levels in the heart tissue were found to be decreased with ovarectomy. Liraglutide treatment maintained nitrate levels in the heart at control levels. In addition, liraglutide administration reduced retroperitoneal fat deposition in OVX rats. Conclusion: Our results showed that GLP-1 administration was effective in reducing the increased blood pressure due to ovariectomy and maintaining the decreased GSH level in the heart tissue.. Therefore, GLP-1 analogs can be considered as potential therapeutic agents in the regulation of blood pressure in the postmenopausal period.

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