Görüntüleme
12
İndirme
4
İridoid glikozitler, doğal olarak yapraklarda, meyvelerde, tohumlarda, ağaç kabuğunda, bitki köklerinde bulunan terpenin 2-siklopentanoid türevleridir. Tıbbi olarak önemlidir, çünkü normalde bitkileri biyotik ve abiyotik ataklardan korurken birçok hastalığın tedavisinde kullanılır. Anti-mikrobiyal, anti-tümör, anti-kardiyak ve anti-enflamatuar etkilere sahiptirler. Ipolamiid, iridoid glikozitlerden biridir ve birçok bitkide doğal olarak bulunur. Ipolamiid biyolojik aktiviteleri açısından çok az bilinen bir bileşiktir. Vücuttaki faydalı mikroorganizmalar ve bitki kökenli bileşikler, insan gastrointestinal kanalında etkileşime girebilir. Probiyotikler, bağırsakların mikrobiyal dengesini geliştirerek birçok sağlık yararına sahip olan canlı mikroorganizmalardır. En bilinen ve en çok çalışılan probiyotikler arasında Lactobacillus acidophilus ve Lactobacillus rhamnosus bulunur. Bu çalışmanın amacı, ipolamiidin probiyotik bakteriler Lactobacillus rhamnosus GG (GG) ve Lactobacillus acidophilus LA-5 (LA-5) üzerindeki etkilerini araştırmaktır. Bu amaçla probiyotiklerin büyümesine farklı konsantrasyonlarda ipolamiid eklenmiş ve bakteriyel büyüme kinetiği, bakteriyel yüzey hidrofobisitesi (Solventlere Mikrobiyel Yapışma - MATS Testi) ve bakteriyel agregasyona (Oto-Agregasyon Testi) etkileri incelenmiştir. Sonuçlar, ipolamidin probiyotik bakterilerin yüzey hidrofobisitesinde önemli bir değişikliğe sebep olmadığını göstermiştir. LA-5 ve GG'nin oto-agregasyon özelliklerinde doza bağlı artışlar gözlenmiştir. Bununla birlikte, ipolamiidin diğer olası biyolojik aktiviteleri hakkında bilgi edinmek için daha ayrıntılı çalışmalara ihtiyaç vardır.
Iridoid glycosites are natural 2-cyclopentanoid derivatives of terpenin found in leaves, fruits, seeds, trees, and plant roots. It is medically important, because it is usually used in the treatment of many diseases while protecting the plants from biotic and abiotic attacks. They have anti-microbial, anti-tumor, anti-cardiovascular and anti-inflammatory effects. Ipolamide is one of the iridoid glycosites and is naturally found in many plants. Ipolamide is a very little known compound in terms of its biological activity. Beneficial microorganisms and plant-based compounds in the body can interact in the human gastrointestinal canal. Probiotics are living microorganisms that have many health benefits by improving the microbial balance of the intestines. The most known and most studied probiotics include Lactobacillus acidophilus and Lactobacillus rhamnosus. The aim of this study is to investigate the effects of ipolamidin on the probiotic bacteria Lactobacillus rhamnosus GG (GG) and Lactobacillus acidophilus LA-5 (LA-5) . For this purpose, ipolamide was added to the growth of probiotics in different concentrations and the effects of bacterial growth kinetics, bacterial surface hydrophobicity (Microbial adhesion to solvents - MATS test) and bacterial aggregation (Oto-Agregation test) were studied. The findings have shown that ipolamide does not cause substantial changes in the surface hydrophobicity of probiotic bacteria. A dose-related increase has been observed in LA-5 and GG’s auto-agregation properties. However, more detailed studies are needed to learn about the other possible biological activities of ipolamide.
Iridoid glycosides are 2-cyclopentanoid derivatives of terpene origin naturally occuring in the leaves, fruits, seeds, bark, roots of various plants. They are medically important because used in the treatment of many diseases while normally protect plants from biotic and abiotic attacks. They have anti-microbial, anti-tumor, anti-cardiac and anti-inflammatory effects. Ipolamiide is one of the iridoid glycosides and naturally present in many plants. Ipolamiide is very little known compound in terms of the biological activities. The beneficial microorganisms in the body and the plant secondary metabolites can interact in the human gastrointestinal tract. Probiotics are live microorganisms that have many health benefits by improving microbial balance of the intestines. Among the most known and most studied probiotics are Lactobacillus acidophilus and Lactobacillus rhamnosus. The aim of the present study is to investigate the effects of ipolamiide on probiotic bacteria Lactobacillus rhamnosus GG (GG) and Lactobacillus acidophilus LA-5 (LA-5). For this purpose, ipolamiide was added to the growth of probiotics in different concentrations and its effects on bacterial growth kinetics, bacterial surface hydrophobicity (Microbial Adhesion to Solvents - MATS Test) and bacterial aggregation (Auto-Aggregation Test) were investigated. The results showed that ipolamiide did not show any important change in surface hydrophobicity of probiotic bacteria. Dose-dependent increases in auto-aggregation properties of the LA-5 and GG were observed. However, further detailed studies are required to give insight into other possible biological activities of ipolamiide.
Alan : Fen Bilimleri ve Matematik; Mühendislik
Dergi Türü : Uluslararası
Makale Detay 
Benzer Makaleler
PDF Görüntüle
Dergi Bilgisi
Eseri Dinleyin
Alıntı Yap
Bu Sayfayı Yazdırın
Paylaş
Mendeley
