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Message 1.Study of influence of the excipients on the pharmaco-technological properties of powder masses during creation of tablets of the goat's rue extract, extract of bilberry leaves and taurine by direct compression method.  The aim of the work. Studying of the influence of excipients on the properties of the tablets mass and main indicators of the tablets in order to develop a new combined pill drug with hypoglycemic activity on the basis of dry extracts of the bilberry leaves, goat’s rue herbs and taurine. Materials and Methods. The main active substances are dry extracts of bilberry leaves and goat’s rue herbs, taurine, excipients (fillers, sliding substances, weeders, lubricants). Investigation of the influence of excipients (E) on such parameters, as fluidity, the angle of natural deviation, free bulk mass, bulk mass after condensation, filling the tablet machine matrix with the powder mass, and the average weight of the tablets after pressing of the powder masses during formation of the tablets of goat’s rue herb extract, extract of bilberry leaves and taurine by direct compression. The research was carried out in accordance with the requirements of the SPF 2 edition. Results and Discussion. The influence of 25 excipients on the pharmaco-technological properties of powder masses (fluidity, the angle of natural deviation, free bulk mass, bulk mass after condensation, the process of filling the tablet machine matrix with the powder mass, the average weight of tablets) with the extract of the goat’s rue herb, extract of bilberry leaves and taurine was studied. The effect of 6 qualitative factors on the basis of basic parameters of powder masses with extract of goat’s rue herb, extract of bilberry leaves and taurine was studied with the help of six-factor experiment – hyper-Greco-Latin square. According to the totality of the studied basic indicators, the best combinations of excipients were selected for further study in order to develop the optimal composition and technology of tablets of bilberry leaves extract, extract of goat’s rue herb and taurine. The obtained results on the characteristics of fluidity of powder masses, the angle of natural slope, the free bulk mass and the bulk mass after sealing indicate the possibility of obtaining the tablets of the extract of goat’s rue herb, the extract of bilberry leaves and taurine by direct compression method.Conclusions. The influence of 25 excipients formed in 6 technological groups at 5 levels was studied. The effect of new excipients that appeared on the pharmaceutical market and were used to create and produce tablets by direct compression was studied for the first time. The excipients which showed the best results of the studied parameters were selected for the further study.

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