Özet:

Rosa damascena Mill, known as the oil rose or Isparta rose, is one of the species of roses that are cultured and economically important among smelled roses around the world. The flying oil derived from the Isparta rose is used in cosmetics, perfumes, pharmaceutical and food industries. Isparta rose is traditionally known to be used in the treatment of chest and abdominal pain, strengthening the heart, constipation, digestive problems, and treating nervous diseases. Although the pathogenesis of Alzheimer’s disease (AD) is not yet clear, one of the accepted theories was the “colinergic hypothesis”. In the brain of Alzheimer’s patients, a deficiency in the neuromedicate levels called acetylcholine (ACh) and butirylcholine (BCh) was observed. The inhibition of acetylcholinesterase (AChE) and butirylcholinesterase (BChE), the basic enzymes that hydrolize ACh and BCh, has become an important treatment option against AD. Therefore, we launched a research to scan the preventive activities of AChE and BChE, key enzymes found in AD pathogenesis. For this purpose, we have studied the inhibitory effects of rose water on these enzymes. The IC50 values were determined as 0.6227 μg ml-1 for AChE as 0.1956 μg ml-1 for BChE.

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