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Akut İskemik İnmeli Hastalarda Trombolitik Tedavi Komplikasyonları ile Laboratuvar Parametreleri Arasındaki İlişkinin Değerlendirilmesi
2022
Journal:  
Journal of Academic Research in Medicine
Author:  
Abstract:

Amaç: İskemik inmeli hastalarda tedavi başarısını öngörmede serum ürik asit ve laktat düzeyleri ile ortalama trombosit hacminin rolünü araştırmayı amaçladık. Yöntemler: Çalışmaya serebrovasküler hastalık tanısı konan ve trombolitik veya trombektomi tedavisi alan 115 hasta dahil edildi. Hastalar komplikasyon gelişen ve gelişmeyen olarak iki gruba ayrıldı. Demografik özellikler, laboratuvar bulguları, Ulusal Sağlık Enstitüleri İnme Ölçeği (NIHSS) kabul ve taburculuk skoru ve Modifiye Rankin Ölçeği (mRS) skoru geriye dönük olarak incelendi. Bulgular: Tüm hastaların %58,1’i erkekti. Gruplar arasında laboratuvar parametrelerinde fark yoktu. Başvuruda NIHSS skoru, taburculukta NIHSS skoru ve mRS skoru, tedavi sonrası komplikasyon gelişen grupta anlamlı olarak daha yüksekti (p<0,05). Laboratuvar değerleri gruplar arasında anlamlı farklılık göstermedi. Erken ölüm oranı komplikasyon gelişen grupta komplikasyon gelişmeyen gruba göre anlamlı derecede yüksekti (p<0,05). Tek değişkenli model, kabul ve taburculukta NIHSS puanının ve mRS skorunun komplikasyonlu ve komplikasyonsuz hasta ayrımında anlamlı etkinliğini ortaya koydu (p<0,05). Çok değişkenli modelde, taburculukta NIHSS skorunun komplikasyonlu ve komplikasyonsuz hasta ayrımında anlamlı ve bağımsız bir etkinliği gözlendi (duyarlılık =%83,3, pozitif tahmin =%30,8, özgüllük =%57,1 ve negatif tahmin =%93,8; p<0,05). Sonuç: Trombolitik tedavi sonrası komplikasyon gelişimi ile laboratuvar bulguları arasında anlamlı bir ilişki bulamadık. NIHSS skoru komplikasyonları öngörmede uygun bir parametre olabilir.

Keywords:

Assessment of the relationship between thrombolytic therapy complications and laboratory parameters in acute ischemic infection patients
2022
Author:  
Abstract:

Purpose: We aimed to study the role of the average volume of thrombocytes with serum uric acid and laktate levels in predicting the success of treatment in patients with ischemic immaculation. Methods: The study included 115 patients diagnosed with cerebrovascular disease and received thrombolithic or thrombectomy treatment. Patients were divided into two groups as the complication developed and undeveloped. Demographic characteristics, laboratory findings, National Institutes of Health’s Admission and Dismissal Score and Modified Rankin Score (mRS) scores were reviewed backward. Results: 58.1% of all patients were male. There was no difference in laboratory parameters between the groups. The NIHSS score in the application, the NIHSS score in departure and the mRS score were significantly higher in the group developing after treatment complications (p<0,05). Laboratory values showed no significant differences between the groups. The rate of early deaths was significantly higher compared to the non-developed group of complications in the developing group of complications (p<0,05). The single variable model demonstrated the meaningful effectiveness of the NIHSS score and the mRS score in the complicated and non-complicated patient distinction (p<0,05). In the multi-variable model, a meaningful and independent effect of the NIHSS score in discharge was observed in the complicated and uncomplicated patient distinction (sensitivity = 83.3%, positive forecast = 30.8%, specificity = 57.1%, and negative forecast = 93.8; p<0.05). The result: We did not find a meaningful relationship between the development of complications after trombolithic treatment and laboratory findings. NIHSS score complications can be a suitable parameter in prediction.

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2022
Author:  
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Journal of Academic Research in Medicine

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

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Journal of Academic Research in Medicine