Özet:

Objective: Helicobacter pylori H. pylori is a microorganism that causes gastric ulcer, duodenal ulcer and atrophic gastritis. The eradication of the bacterium is difficult and it is usually necessary to use multiple antibiotics for 14 days to eradicate it. The aim of this study was to determine the eradication success of the classical triple therapy of H. pylori eradication in and around Tokat province.Material and Methods: The data of the patients who underwent upper endoscopic examination at the Medical Faculty of Tokat Gaziosmanpasa University between January 2012 and December 2016 were analyzed retrospectively. The patients who diagnosed as H. pylori positivity by histopathological examination of the endoscopic biopsy specimens treated with lansoprazole, amoxicillin, and clarithromycin combination were evaluated and patients who were controlled within 3 months for H. pylori eradication were included in the study. Results: A total of 218 patients 131 female, 87 male were included in the study. The mean age of the patients was 43.7 years. H. pylori eradication was detected in 188 86.2% of 218 patients. There was no significant difference in treatment success between men and women p= 0.417 .Conclusion: There are many different treatment regimens in the eradication of H. pylori. Success rates with classical triple therapy vary among regions due to antibiotic resistance and changes in liver enzyme metabolism. This study is important in terms of showing that the classical triple therapy in Tokat is an effective treatment option and may be preferred as a first-line in the treatment of H. pylori