Abstract:

Introduction: Deep vein thrombosis (DVT) is a common complication found in malignancy patients. If not handled properly, this condition can be fatal. As many as 1-8% of cases developed into pulmonary embolism and cause death. Malignancy associated thrombosis is second leading cause of death in patients with malignancy. Ovarian clear cell carcinoma has the highest risk of thrombosis compared to other carcinomas, 5-16% of patients with ovarian malignancy. This condition is aggravated by liver metastasis. Case: 36-year-old woman with left ovarian clear cell carcinoma stage IVB, get a series of Carboplatin and Paclitaxel chemotherapy, complained severe pain in the left leg that progressively increase with edema and erythema from the thigh to the calf. Patient was diagnosed as suspected DVT with Wells’ scores 5 that supported by an increase in D-dimer and bilateral lower extremity venous doppler ultrasound showing DVT in the communal femoral, superficial femoral, and popliteal veins of the left leg. Abdominal CT scan result show liver metastasis with massive ascites. The patient was treated with 2 x 40 mg furosemide, 5000 units of heparin bolus followed by 20000 units of heparin drip / 24 hours and 1 x 2 mg bridging Simarc. PT and APTT result show prolongation. Conclusion: We reported a case of DVT in left ovarian clear cell carcinoma stage IVB with liver metastasis. This case emphasizes coagulopathy manifestation in malignancy that can be caused by cancer management and the use of anticoagulants that are aggravated by liver metastasis.

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