Özet:

Objective Covid-19 disease is diagnosed by moleculer, serologic or radiological methods. However, these diagnostic methods cannot be reached everywhere or take too much time to result. So, we need for effective diagnosis of Covid-19 patients with simple and easy accessible laboratory biomarkers. Therefore, we investigated the diagnostic performance of Eosinophilic Cationic Protein (ECP) in Covid-19. Material and Methods Our study is a retrospective case-control study. The recorded clinical, laboratory and radiological data of 30 patients who were diagnosed with Covid-19, between 15 March and 15 June 2020, were compared with 30 healthy person by using appropriate statistical methods. Results Both patients and conrols included 10 (33.3%) females and 20 (66.6%) males with a mean age of 57.2 ± 15.46 and 60.07 ± 20.59 respectively. Eosinophil counts of the patients at admission were significantly lower than the controls (p <0.001). Eosinophil counts one week after admission were increased significantly compared to the admission levels (p= 0.004). ECP values of the patients one week after admission were significantly lower than controls and decreased compared to the admission (p= 0.023, p= 0.001respectively). ECP values of one week later, differentiated patients and controls with 46.7% sensitivity, 93.3% specificity and a cutoff value of ≤ 88.67 ng/mL. ROC analysis of ECP2; (AUC)= O.740, p= 0.023. Conclusion It will be of great benefit in terms of public health that suspected patients of Covid-19 are quickly isolated from other patients with similar symptoms, with a simple ECP test and started taking empirical treatment.

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