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Objectives: The aim of this study was to evaluate the most ideal inflammatory markers for treatment response and to determine a cutoff value that could predict response to treatment for culture negative neutrocytic ascite (CNNA) patients. Methods: This is a retrospective cross-sectional case-controlled study. Patients with CNNA were evaluated by taking ascites fluid sampling at the beginning and on the 5th day of treatment. Neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and neutrophil-to-monocyte ratio were calculated. Results: Of the 123 cases with cirrhotic ascites disease, 59 were CCNA and 64 were the control group without ascite-fluid infection. There were statistically significant differences for blood monocyte count, NLR (p<0.01), LMR, and C-reactive protein (CRP) (p<0.001) between two groups. Patients in the CNNA group were compared before and after treatment among themselves for the treatment response. There was statistically significant difference in mean platelet volume, monocyte, LMR, and CRP (p<0.05) between two groups. After receiver operator characteristics curve analysis, the best cutoff value for monocyte was <0.64 × 10³/µL (sensitivity 49.2%, specificity 74.6%, positive predictive value [PPV] 65.9%, and negative predictive value [NPV] 59.5%) (p<0.01), for LMR was ≥1.7 (sensitivity 76.3%, specificity 78%, PPV 77.6%, and NPV 76.7%), and for CRP was ≤18 mg/L (sensitivity 91.5% specificity 57.6%, PPV 68.4%, and NPV 87.2%) (p<0.001). When LMR and CRP were used together, sensitivity (86.5%), specificity (83.1%), PPV (83.6%), and NPV (86%) were found to be statistically significantly higher (p<0.001). Conclusion: Our results showed that in cirrhotic patients with CNNA, combined LMR + CRP can be used as a novel, low cost and non-invasive test to predict treatment response.
Purpose: The aim of this study was to evaluate the most ideal inflammatory indicators for the treatment response in patients with culture negative neutrotic acid (KNNA) and to determine a cutting value that can predict the treatment response. Method: This study is a retrospective, cutting-edge, case-controlled study. Patients with KNNA were evaluated by taking an acid fluid sample at the beginning and on the 5th day of treatment. The neutrophil-lenphocytes rate (NLR), the lymphocytes-monocytes rate (LMR) and the neutrophil-monocytes rate were calculated. Results: 59 of the 123 vacancies with syrotic acid disease were KNNA, and 64 were non-acid-fluid infection control groups. The number of blood monocytes between the two groups had statistically significant differences in terms of NLR (p <0,01), LMR and C-reactive protein (CRP) (p <0,001). Patients in the KNNA group were compared with each other before and after treatment for treatment response. There were statistically significant differences between the two groups in terms of the average volume of thrombocytes (MPV), monocytes, LMR and CRP (p <0.05). After the ROC curve analysis, the best cutting value for monocyte was <0,64 103 / μL (sensitivity%49,2, specificity%74,6, PPV%65,9, NPV%59,5) (p <0,01) for LMR ≥1,7 (sensitivity%76,3, specificity%78, PPV%77,6, NPV%76,7) and for CRP 18 mg / L (sensitivity%91,5 specificity%57,6%, PPV%68,4, NPV%87,2) (p<0,001). When both LMR and CRP were combined, sensitivity (86,5%), specificity (83,1), PPV (83,6) and NPV (86) were statistically significantly high (p <0,001). Results: Our findings showed that combined LMR + CRP can be used as a new, low-cost and non-invasive test to predict the therapeutic response in patients with KNNA. (SETB-2021-02-050)
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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