Abstract:

Objective: Despite the improvements in the treatments of surgical and intensive care, sepsis and systemic inflammatory response syndrome are the most common cause of mortality. Therefore in the experimental animal model, we aimed to reveal biochemical and histopathologic effects of strontium ranelate on healing in experimental animal model for peritonitis and sepsis. Method: 20 female Wistar-Albino rats were used.Rats were seperated into 4 groups; control, sham [ceacum ligation perforation (CLP)], CLP + Strontium (S) (CLP+S) and S+CLP+S. Rats were euthanised on 7th day. Peritoneal inflammation staging and ileum resection was performed. Blood samples were taken for biochemical screening and IL-1, IL-6, IL-10 and TNF-alpha tests were evaluated. Results: Peritoneal inflammation score was the  highest at CLP group and the lowest at control group. There was healing in CLP+S group compared to CLP group, and more healing in S+CLP+S group compared to CLP+S group. According to histopathological evaluation, ileum injury was the lowest in the control group and the highest in CLP group. Less injury was found in CLP+S group compared to CLP group, and less injury was found in S+CLP+S group compared  to CLP+S group. No difference was found when TNF-alpha, IL-1, IL-6 and IL-10 values were compared. Conclusions: Strontium ranelate may reduce mortality and morbidity by prophylactic treatment in patients at risk of sepsis and patients with sepsis.

Keywords: