Özet:

We observed a case of tardive dyskinesia after regular use of low dose chlorpromazine. An anticholinergic agent; trihexyphenidyl (THX) was prescribed to treat the tardive dyskinesia. The treatment response was satisfactory, but brief hypomanic episodes occurred. Because the patient was symptom free for long periods of time, we suspected that THX might have had a negative effect on the course of the disease or it might have induced hypomania. The hypomanic episodes were controlled with short term use of olanzapine. When the dose of THX was further increased, elevation of mood occurred. The history of bipolar disorder in his family and having the early onset type of bipolar disorder were features of our case that made the tardive movement disorder more likely. Although THX may be an effective option in tardive dyskinesia, possible impact on the course of the disorder in bipolar patients should be considered.

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