Özet:

Goal: Groupe B streptococcus (GBS), which can be colonized in the intestinal and vaginal flora of healthy adults, cause soft tissue infections and urinary tract infections, especially in newborns with meningitis and sepsis, pregnancy and underlying disease. Penicillins are the first preference in the treatment of GBS infections. However, the recently decreased sensitivity of penicillin, increased resistance rates to alternative agents, and the knowledge of their antibiotic sensitivity due to patients with penicillin allergy are important in order to give guidance to treatment. This study aims to assess the antibiotic sensitivity of GBS isolates isolated in our laboratory. Method: Antibiotic sensitivity of a total of 166 GBS isolates, isolated from various clinical samples from our laboratory between January 2017 and June 2018, was assessed.Bacterial detection and antibiotic sensitivity tests were performed using conventional methods and VITEK 2 (BioMérieux, France).®The European Committee on Antimicrobial Susceptibility Testing (EUCAST) tested the disc diffusion method.Resistance phenotypes were determined by the double disk synergy method (D test) in case of macrolids resistance was determined.Results: In the study, all GBS isolates were found sensitive to penicillin, vancomycin, tigesiclin and linezolide.The sensitivity to nitrofurantoin, levofloxacin and norfloxase was 94.5, 78.3 and 77.7 per cent respectively. The resistance to erythromycin and clindamycin was 35.5% and 30.7% respectively; the iMLSB ratio was 73%. The result: In our study, the resistance of penicillin in the GBS isolates was not found. The levels of resistance to erythromycin, clindamisine and levofloksase indicate that caution should be made in cases where these medications are used for prevention and treatment. Therefore, antibiotic sensitivity tests are recommended to guide the selection of medications to be used in the clinic and to determine the GBS resistance profile.

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